Journal article
Functional Neuroanatomy of the Rat Nucleus Incertus–Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway
A Szlaga, P Sambak, A Trenk, A Gugula, CE Singleton, G Drwiega, T Blasiak, S Ma, AL Gundlach, A Blasiak
Frontiers in Cellular Neuroscience | Published : 2022
Open access
Abstract
The medial septum (MS) is critically involved in theta rhythmogenesis and control of the hippocampal network, with which it is reciprocally connected. MS activity is influenced by brainstem structures, including the stress-sensitive, nucleus incertus (NI), the main source of the neuropeptide relaxin-3 (RLN3). In the current study, we conducted a comprehensive neurochemical and electrophysiological characterization of NI neurons innervating the MS in the rat, by employing classical and viral-based neural tract-tracing and electrophysiological approaches, and multiplex fluorescent in situ hybridization. We confirmed earlier reports that the MS is innervated by RLN3 NI neurons and documented pu..
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Awarded by Narodowym Centrum Nauki
Funding Acknowledgements
This research was supported by research grants from the National Science Centre, Poland (UMO-2018/30/E/NZ4/00687 to AB, UMO-2019/33/B/NZ4/03127 to TB, and UMO-2017/27/N/NZ4/01545 to AG), the Institute of Zoology and Biomedical Research of the Jagiellonian University, Krakow (N18/MNS/000032 and N18/MNW/000025 to PS, and N18/MNS/000035 to AS), and the National Health and Medical Research Council of Australia (1067522 to ALG). AT was supported by the National Science Centre (Poland) Doctoral Scholarship ETIUDA VI (UMO-2018/28/T/NZ4/00382). The Florey Institute of Neuroscience and Mental Health was supported by the Victorian Government Infrastructure Fund.